The regulatory network around these cyclins, particularly in G1, has been interpreted as a size control network in budding yeast , and cell size as being decisive for the START transition.

Cell sizes emerge in the model, which predicts that a single CDK-cyclin pair per growth phase suffices for size control in budding yeast , despite the necessity of the cell cycle network around the cyclins to integrate other cues.

Recent evidence strongly suggests that also in budding yeast size control is likely to be exerted outside of G1 [9, 10].

The fission yeast Schizosaccharomyces pombe has a size control checkpoint at the G2/M boundary and many of its components are conserved in budding yeast [11, 12].

The observation that the budded phase duration responds to growth media and the high degree of conservation between the two yeasts prompts the question, whether a size control mechanism guards mitotic entry in budding yeast as well [13—16].

Budding yeast grows and divides asymmetrically and, therefore, growth of the mother and the bud is considered separately [39].

Our in silico analysis carried out genome-wide via the StabFIex algorithm, shows the conserved presence of highly flexible regions in budding yeast genome as well as in genomes of other Saccharomyces sensu stricto species.

Here, we study DNA flexibility in budding yeast chromosomes.

In budding yeast , the ability of genes to respond to environmental changes has been related to nucleosome occupancy in 5’ ends and 3’ - ends [42, 43].

In this paper we approach the problem of biological meaning of DNA helix flexibility by analysing budding yeast chromosome sequences.