| Author Summary | High DNA helix torsional flexibility characterizes sequences Which are enriched in fragile sites, loci of peculiar chromosome instability inside human genome often associated With cancer genes . |
| Author Summary | AT-rich flexible islands are suggested to be the determinants of chromosome fragility; however, the origin of their occurrence in cancer genes and the mechanism of chromosome breakage remain unknown. |
| Author Summary | They suggest that functional processes may be also at the origin of flexibility peaks presence inside cancer genes in human fragile sites. |