| Analyzing the sensitivity towards perturbations | Interestingly, we further observe that crucial nodes whose removal will be most destructive are generally not part of the largest connected component of the initial seed set. |
| Interaction patterns of disease proteins within the Interactome | Examining the subgraphs consisting of proteins associated with the same disease, we found that the largest connected component (LCC) typically contains only 10%-30% of the disease proteins (Fig. |
| Validating disease modules | The largest connected component of the seed proteins aloneconsists of 24 (out of 45) proteins. |
| Validating disease modules | When 200 DIAMOnD proteins are added, the largest connected component of the resulting module integrates 11 additional, previously disconnected seed proteins, resulting in a module consisting of 234 proteins (Fig. |