Transcripts are characterized by decreased halflife: this is considered peculiar of genes involved in regulatory systems with high turnover; consistently, their function affects biological processes such as cell cycle regulation or stress response.

More, we show that ORFs with peak in 3’ UTR share a number of common functions in biological processes such as cell cycle regulation or stress response.

The second one is their enrichment in genes related to cell cycle regulation , apoptosis or similar processes involved in cancer development [65].

The G2 size control is implemented analogously to the G1 sizer, through biosynthet-ic capacity dependent production of a critical cell cycle regulator .

It is not exactly clear how growth can flip a transition switch, but one theory for size control proposes the level of an unstable cell cycle regulator as a gating device to measure the growth capacity of the cell [25, 26].

In the model, growth and proliferation is integrated through production of a critical unstable cell cycle regulator as function of the biosynthetic capacity of the cell.