| Discussion | This circular correlation coefficient would not be a convenient metric for cytoskeleton or cellular orientation quantification. |
| Discussion | In a healthy, properly functioning cell or tissue, the cytoskeleton needs to be organized in an intricate manner. |
| Experimental Results | Indeed, most images of cytoskeleton constructs are obtained via immunostaining and imaging. |
| Introduction | The architecture and organization of the cytoskeleton components in cells, the cells in tissues, and cellular ensembles in organs affect function at each of these physiological scales [1—4]. |
| Introduction | Furthermore, for proper function, different components of the cytoskeleton , cell, or tissue need to co-localize and orient properly with respect to each other [5, 6]. |
| Introduction | The suite of correlation parameters provided by circular statistics are either too limited to be used with cytoskeleton organization or so complex the results are hard to connect back to biological phenotypes [21]. |