Biological validation analysis | First we identify the set of GO terms (pathways) that are significantly enriched within the given set of seed genes using Fisher’s exact test (Bonferroni corrected p-value<0.5). |
Biological validation analysis | The statistical significance of an observed number is then determined using Fisher’s exact test. |
Interaction patterns of disease proteins within the Interactome | We found that only between ~ 1%-5% of the communities detected by the different methods are significantly enriched (p-value < 0.05, Fisher’s exact test) with any set of disease proteins (Fig. |
Pairwise covariation | But, as the total sample size tends to infinity, ranking based on LR is asymptotically equivalent to ranking based on Fisher’s exact test of independence [64]. |
Supporting Information | PR-PR pairs ranked by Fisher exact test p-Value calculated from 2013 HIVDB sequences. |
Supporting Information | We show a comparison between PR-PR pair rankings calculated using Fisher’s exact test on a MSA provided by the Stanford HIVDB [24] dated 4/29/2013 and the permutation test |