| Interactome construction | Binary interactions: We combine several yeast-two-hybrid high-throughput datasets [10,39—42] with binary interactions from IntAct [43] and MINT [44] databases. |
| Interactome construction | Signaling interactions: The dataset from [50] provides 32,706 interactions between 6,339 proteins that integrate several sources, both high-throughput and literature curation, into a directed network in which cellular signals are transmitted by proteins-protein interactions. |
| Introduction | With recent advances in genome-wide disease gene association [9] and high-throughput Interactome mapping [10] we can already pinpoint the approximate location for some disease modules (Fig. |