General asynchronous updating scheme | In the general asynchronous scheme, the state of the nodes is updated at discrete time steps starting from an initial condition at t: 0. |
General asynchronous updating scheme | At every time step, one of the variables is chosen randomly (uniformly) and is updated using its respective function and the state of its regulators at the previous time step |
Intervention target validation | To validate an intervention target, we fix the node states prescribed by the intervention, choose a random (uniformly chosen) initial condition, and evolve the system using the general asynchronous updating scheme for a sufficiently large number of time steps so that the system reaches an attractor. |
Intervention target validation | We find that, for our test cases, temporal evolution for 10,000 time steps ensures reaching an attractor from any initial condition considered with stable motif control intervention or without an intervention; to be safe, we choose to evolve for 50,000 time steps in all cases. |
Intervention target validation | it is transient), that is, we fix the prescribed node states for a large number of time steps, then stop fixing these states and wait for another large number of time steps for the system to reach an attractor. |