Conclusion | This study, and other large-scale gene expression or proteomic studies that include network and pathway analysis [82,83,114] and gene ontology [115], will help determine likely control points for cell growth, migration, and differentiation in individual tumors. |
Data Analysis and Clustering | Gene Ontology (G0) was determined as described [34]. |
Embedding and Cluster Analysis | Clusters were evaluated internally, based on the primary data, and externally, using PPI and gene ontology (GO) databases (SS Fig). |
Introduction | By combining pattern recognition techniques with gene ontology (GO) and protein-protein interaction (PPI) data, we learned that clusters that contain interacting proteins are likely to indicate functional signaling pathways [34—40]. |
Supporting Information | Gene ontology summaries of clusters. |
Characteristics of host proteins interacting with known B. mal/ei virulence factors | First, we applied functional enrichment analyses based on Gene Ontology (GO) annotation data [23] to assess the characteristics of the human proteins targeted by the nine virulence factors. |
Supporting Information | A list of interaction modules statistically significantly enriched in Gene Ontology (GO) biological processes for human proteins interacting with known B. mallei virulence 82 Table. |
Supporting Information | Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways statistically significantly enriched in human proteins interacting with known and/ or putative B. mallei Virulence factors. |
Supporting Information | Subnetworks statistically significantly enriched in Gene Ontology (GO) biological processes for human proteins interacting with known and/ or putative B. mallei Viru-SS Table. |
Kinetics and chromatin features underlying IEG induction | (2007) [10], we constructed a set of 444 genes assigned with the Gene Ontology annotation for nucleotide binding GO:0000166 (IEA assignments were excluded). |
The early peak signature is enriched for lEGs and signalling pathways | Gene ontology terms associated with early peak clusters that were significantly over-repre-sented in HRG treated MCF7 cells are listed in 81 Table, see also S6 Fig (analysis performed with GOrilla [22] and REVIGO [23]). |
peak category. | Gene Ontology process term enrichment in MCF7-HRG cells. |