| A real life example: Escherichia coli growing on glucose | For these growth conditions , general CoPE-FBA results for both the model with and without reversible-reaction splitting are shown in Table 1. |
| A real life example: Escherichia coli growing on glucose | With splitting we found for each growth condition many more vertices (up to 120 X 106). |
| A real life example: Escherichia coli growing on glucose | Without this constraint, all vertices in both the aerobic and anaerobic growth condition are instances of their corresponding EFMs (not shown). |
| Characterization of the optimal solution space: Illustration with a toy model | an anaerobic growth condition ) effectively removes a reaction from the system. |
| Author Summary | In our model, a growth condition specific cell size emerges, as has been found in experiments. |
| Discussion | Yet, simply regulating G2 length in response to growth conditions does not seem to be the end of the story. |
| mCLB localization is required to equilibrate S-Gz-M duration between generations | Both model versions show adaptation of S-GZ-M duration to growth conditions (Fig 3). |
| mCLB localization reduces noise at mitotic entry to stabilise cell size | Model and data could only be reconciled when we adapted S-GZ-M duration to growth conditions . |
| mCLB localization reduces noise at mitotic entry to stabilise cell size | Thus, we hypothesised that, for a robust setting of average cell size and variability within the culture, S-GZ-M duration must show some form of adaptation to growth conditions . |
| Introduction | Under favorable growth conditions , microorganisms can grow rapidly. |
| Introduction | For example, E. coli cells can grow as fast as ~ 20 min per doubling under ideal growth conditions . |
| Strain, media, and growth condition | Strain, media, and growth condition |