Finally, the stable motif control interventions for our case studies target only a few nodes (between one and five out of more than fifty), which matches what is expected from stem cell reprogramming experiments [1—3, 8].

The validity of the control targets on the translated ODE models of our two case studies and the experimental support found for several of these targets demonstrates the broader, potentially model-independent reach of our method.

It should be noted that our method does not guarantee that the resulting control sets are small nor that the control sets are the smallest possible, though our case studies suggest that the resulting control sets tend to be relatively small (between one and five nodes out of more than fifty, see Tables 1 and 2, and ref [45]).

We analyse factors underlying the effectiveness of reactive eradication of localised outbreaks of invading plant disease, using citrus canker in Florida as a case study, although our results are largely generic, and apply to other plant pathogens (as we show via our second case study , citrus greening).

Although our methods and analyses are generic, we use the attempted eradication of citrus canker from Florida (1996—2006) as a case study , and focus upon the performance of reactive culling (i.e.

Here we use the citrus canker system as a case study to illustrate general principles underlying the effectiveness of control.