Cell sizes emerge in the model, which predicts that a single CDK-cyclin pair per growth phase suffices for size control in budding yeast, despite the necessity of the cell cycle network around the cyclins to integrate other cues.

It emerges as a combination of the cell cycle , controlling the orderly orchestration of duplication and division, and the individual growth rate, reflecting extra and intracellular physiological conditions.

The cell cycle and the growth rate are coupled, such that proliferation and growth are balanced, avoiding abnormally large or small cells.

First, the cell cycle as well as cellular growth are two fundamental properties that can be found in nearly all forms of life.

In particular we analyze two datasets: the cell cycle dataset in yeast, a common model organism, and a well characterized human leukemia dataset.

Yeast T Fs are cooperative during cell cycle .

We used Loregic to characterize the TF-TF-target logics during the yeast cell cycle (Materials and Methods) and found 4,126 TF-TF-tar-get triplets that are gate-consistent (Fig.

We apply Loregic to study regulatory factors (TFs and miRNAs) in the yeast cell cycle and human cancer datasets.

We apply Loregic to find the logic operations that characterize the FFLs from a genome-Wide perspective in both the yeast cell cycle and human leukemia cancer datasets.

Transcripts are characterized by decreased halflife: this is considered peculiar of genes involved in regulatory systems with high turnover; consistently, their function affects biological processes such as cell cycle regulation or stress response.

More, we show that ORFs with peak in 3’ UTR share a number of common functions in biological processes such as cell cycle regulation or stress response.

The second one is their enrichment in genes related to cell cycle regulation, apoptosis or similar processes involved in cancer development [65].

Coherently with the above described functional aspects, flexibility peaks in yeast occur in ORFs involved in cell cycle control or stress response, where flexible sequences seemed to play a regulatory role in gene expression.

The outcomes for Biological Process GO terms (visualized as treemap in supporting 81 file, figure 6, top) point out the presence of ORFs with role in cell cycle , phosphorus/ organic cyclic compound/ nitrogen compound metabolism, phosphorylation reproduction, growth, response to acid, signaling.

The 175 ORFs include genes expressing key components of cell cycle progression and regulation: TUBZ and TUB3 encoding a and fl tubulins, CLB4 and PH 080 encoding cyclins, CDC53 and APC9 encoding respectively the cullin structural protein of SCF complexes and a subunit of the Ana-phase-Promoting Complex/Cyclosome; moreover, AME] , RAD24, RAD59 and SWEI involved in checkpoint maintenance, the F U83, DI G2 and SLT2 encoding MAP-kinases and their regulator BMH1 encoding the major isoform of 14-3-3 proteins.