| Characterization of the optimal solution space: Illustration with a toy model | Both sets of reactions have an identical input-output relationship : D + ADP —> H + ATP. |
| Characterization of the optimal solution space: Illustration with a toy model | We identified three different mechanisms that contribute to the increase in vertices: (i) splitting can yield additional CoPE-FBA subnetworks that originate from rays or linealities with a input-output relationship different from zero. |
| CoPE-FBA 2.0 pipeline | In the constructed Ecoli subnetworks, the input-output relationship was the only constraint. |
| CoPE-FBA subnetworks and F-modules | CoPE-FBA subnetworks are defined Within this flux space and have a fixed input-output relationship , Which we can write mathematically as: |
| CoPE-FBA subnetworks and F-modules | Subsequently, N A and I A are the stoichiometric matrix and the flux vector of the subnetwork, and d is the fixed input-output relationship of the subnetwork. |