| Ordinary differential equation model selection | We applied an adaptation of a likelihood ratio test (LRT) with a threshold of 95%, which takes into account the different degrees of freedom for each model structure (Materials and Methods). |
| Ordinary differential equation modeling | The result of each pairwise likelihood ratio test is then used to obtain the ranking of the corresponding model structures. |
| Supporting Information | The models are sorted according to the Likelihood ratio test value as 81 Fig. |
| Supporting Information | Values of the likelihood ratio test with the threshold of 95% are shown under each corresponding model. |
| Supporting Information | P-Values were computed using either a Score test (A) or a Likelihood Ratio test (B). |
| Supporting Information | Because the Likelihood Ratio test appeared to have significantly more power than both the Score test and the MAGMA F-test, empirical p-Values for the Likelihood Ratio test were computed by generating up to 10,000 permutations of the Likelihood Ratio statistic. |
| Supporting Information | This was compared to the asymptotic Likelihood Ratio test p-Values (C), revealing a downward bias in the asymptotic p-Values. |