Index of papers in April 2015 that mention
  • steady state
Jyotika Bahuguna, Ad Aertsen, Arvind Kumar
AMSN
It should however be noted, that our model eXplores the DTT under steady state conditions only.
Effect of Dopamine on the DTT
This steady state effect of dopamine is often modelled by changing the weight of cortico-striatal synapses for D1 ([0) and for D2 (ICZ) [27].
Effect of Dopamine on the DTT
Consistent with experimental observations, our model suggests that an increase in steady state dopamine levels would (1) increase the firing rate of D1 MSNs [28] , thereby (2) introducing a preference for ‘Go’ type actions or dyskinesia.
Model limitations
Thirdly, our model explores the striatal dynamics at steady states , since the model showed stable fixed points.
Model predictions and explanation of experimental data
In our model, an increase in the steady state level of dopamine changes the DTT to higher cortical input rates, thereby increasing the region in which D1 MSNs can have their firing rate exceed those of D2 MSNs (Fig 7A).
Model predictions and explanation of experimental data
In our model, a decrease in the steady state dopamine level results in an increase in the range of cortical input for which D2 MSNs have a higher firing rate than D1 MSNs.
steady state is mentioned in 6 sentences in this paper.
Topics mentioned in this paper:
Lorenza A. D’Alessandro, Regina Samaga, Tim Maiwald, Seong-Hwan Rho, Sandra Bonefas, Andreas Raue, Nao Iwamoto, Alexandra Kienast, Katharina Waldow, Rene Meyer, Marcel Schilling, Jens Timmer, Steffen Klamt, Ursula Klingmüller
Discussion
Other modeling approaches using perturbation data to unravel the network structure rely on modular response analysis (MRA), which requires steady state assumptions and linear equation based modeling.
Discussion
Positive feedback loops have been shown to cause bistable behavior [49] and must be contained in the system's structure to enable more than one steady state [50].
Introduction
In contrast to related methods, which rely on the concept of sign consistency and require a steady state assumption [30, 34], exploitation of the dependency matrix is well-suited for the analysis of transient effects.
Ordinary differential equation modeling
During the parameter estimation, no steady state conditions have been utilized.
Ordinary differential equation modeling
We assume that non-stimulated measurements of signalling components in our data set is sufficient for training the system to an initial steady state in an unstimulated setting.
steady state is mentioned in 5 sentences in this paper.
Topics mentioned in this paper:
Kevin Thurley, Daniel Gerecht, Elfriede Friedmann, Thomas Höfer
Competitive lL-2 uptake by regulatory T cells
Fig 3), the IL-2 concentration attains a spatially inhomogeneous steady state more rapidly, with the overall IL-2 concentration being lower (Fig 4C and 4D and 82A Fig).
Discussion
In contrast to immune cell signaling with a typical time scale of many hours during which diffusive gradients reach steady state , the transient behavior on shorter time scales is of particular interest for morphogen gradients [51,54].
Homogeneous cytokine secretion and uptake
As diffusion is fast (D = 10um2/s, see Table 1), it reaches a steady state after about LZ/D = 0.5 s, Where L is the cell-to-cell distance in the case of high cell-density.
Homogeneous cytokine secretion and uptake
Thus, it is sufficient to consider the diffusion equation in steady state in the extracellular domain with flux boundary condition at the cell surface: c(r) is the cytokine concentration at distance r from the center of the cell, A is the Laplace operator in spherical coordinates, p is the cell radius, and q is the cytokine secretion rate.
steady state is mentioned in 4 sentences in this paper.
Topics mentioned in this paper: