| Discussion | However, a positive synergistic effect is predicted only for some combinatorial treatments suggesting robustness. |
| Inhibitor combination: model predictions and experimental validation | In some cases, we observed synergistic effects as the combination of inhibitors had a stronger effect on the readout than the sum of impact of the respective individual inhibitions. |
| Inhibitor combination: model predictions and experimental validation | To address the synergistic effect of the inhibitor combination treatment, we calculated the effect of the inhibitor combination compared to the single inhibitor treatment (Fig 8B). |
| Inhibitor combination: model predictions and experimental validation | Interestingly, we observed that the Ras inhibitor has a synergistic effect on pAkt and pERK with several other inhibitors such as Raf1, ERK and Rac inhibitors. |
| Introduction | However, the discovery of synergistic effects is not trivial. |
| Introduction | However, it has been shown that under certain feedback conditions, strong synergistic effects will be seen between upstream and downstream points that are located serially along a pathway [7]. |
| Introduction | The second step in identifying useful combinations was to experimentally evaluate synergistic effects [29,30]. |