| Computational model | Each synaptic input was modeled as a time-varying conductance fit to an alpha function: with a time constant 5 ms and an amplitude determined by the excitatory input parameter of the model (ranging from 0.3 to 6 n8). |
| Computational model | NMDA channels were added to the model only for S6 Fig (e-f.) The time constants used for the alpha function governing the time varying conductance for the NMDA channel was 63 ms (fast component) and 200 ms (slow component), with a peak amplitude ratio of 0.88:0.12 (fast: slow). |
| Computational model | The ratio of the peak amplitude between the AMPA channel ( time constant of 5 ms) and NMDA channel was 1:0.3 (AMPA:NMDA) [29]. |
| Methods). | The synchronization limit of simulated neurons was also sensitive to this time constant; increasing this time constant (S6 Fig, ad) or adding an additional NMDA-based conductance (S6 Fig (e-f) [29], see Methods) shifted the synchronization limit of simulated neurons to longer IPIs (mean synchronization limit: sync = 15.9 ms, mixed 2 15.3 ms). |
| Results | We tested our model With acoustic pulse trains spanning the perceptual range of flutter/ fusion perception, with interpulse intervals (IPIs) ranging between 3—75 ms. Each acoustic pulse was modeled as a change in the excitatory and inhibitory conductance, governed by an alpha function with a 5 ms time constant (Fig. |
| Supporting Information | Dependence of synchronization limit on conductance time constant . |
| Supporting Information | Simulated synchronizing neuron With IE delay 2 5 ms, excitatory strength 2 3 n8, I/E ratio = 1.7. a. Raster plot of acoustic pulse train response, 5 ms time constant used for input conductance. |
| Supporting Information | b. Raster plot of acoustic pulse train response, 10 ms time constant used for input conductance. |
| Stellate cells express significant non-linear membrane properties leading up to spike threshold | For current inputs eliciting small changes in voltage (5 mV), the resulting voltage trajectory was fit accurately with an exponential function and used to extract the membrane time constant near -75 mV (12.0 i 0.9 ms, n = 19). |
| Stellate cells express significant non-linear membrane properties leading up to spike threshold | Thus, the voltage trajectories to spike threshold starting either from resting voltages or the trough of the AHP were relatively linear compared to that expected from our measures of the membrane time constant at—75 mV. |
| a co g-n —stellate v,, trajectory | For comparison, the exponential approximation using the membrane time constant measures taken at -75 mV is also shown. |