Using a simplified budding yeast cell cycle model perturbed by intrinsic noise, we systematically explore these issues from an energy landscape point of view by constructing an energy landscape for the considered system based on large deviation theory.

We performed a careful study of the budding yeast cell cycle process from an energy-landscape point of view.

The energy landscape of the budding yeast cell cycle is mainly comprised of two parts on a global scale: a deep pit that holds a cell in its G1 state when the environment is not suitable for division, and one unidirectional flat canal that performs a robust and accurate cell cycle progress once the system is excited (as summarized in Fig.

Even with such limitations, we believe our meticulous study of the energy landscape of the simplified budding yeast cell cycle model is of general interest to those studying other complicated cell cycle dynamics.

Using the described method, we constructed the energy landscape S(x) for a budding yeast cell cycle network.

Using a simplified budding yeast cell cycle model driven by intrinsic noise, we systematically explore the above issues from an energy landscape point of view by constructing a global quasi-potential energy landscape for the budding yeast cell cycle model.

Overall, our energy landscape study shows that the budding yeast cell cycle is a robust, adaptive and multistage dynamical process.

We first assume that the DNA replication triggers the mitosis as a “domino” mechanism in the budding yeast cell cycle.

Based on the key regulatory network [17] and our previous study on budding yeast [22] , the cell cycle regulatory network can be simplified and separated into G1 /S, early M and late M modules, as shown in Fig.

The three-node Budding Yeast Cell Cycle Model, 11.

The regulatory network of cell-cycle process in budding yeast .