Burkholderia pathogenicity relies on protein virulence factors to control and promote bacterial internalization, survival, and replication within eukaryotic host cells.

Burkholderia species need to manipulate many host processes and pathways in order to establish a successful intracellular infection in eukaryotic host organisms.

This host-adapted bacterium is equipped with an extensive set of mechanisms for invasion and modulation of eukaryotic host-cell environments.

Using multiple virulence factors to target eukaryotic-specific mechanisms common to eukaryotic rhizosphere species, B. mallei broadly influences key processes in ubiquitination and cell signaling to modulate and adapt the host-cell environment for its benefit.