| Abstract | The theory is generally applicable and amenable to predictions if the dose-response curve for gene repression is noncooperative with a unit Hill coefficient , which is observed for GR-regulated repression of AP1LUC reporter induction by phorbol myristate acetate. |
| Discussion | This is supported by the observation of noncooperative dose-response curves with unit Hill coefficient in both GR-mediated repression (Fig. |
| Discussion | The binding of preformed GR dimers would yield a dose-response curve with greater than unity Hill coefficient . |
| Introduction | The theory is based on the fact that the dose-response curve for gene induction is noncooperative With a Hill coefficient of one [20]. |
| Non-cooperative dose-response | Experimentally, the dose-response of gene activity A in steroid-regulated repression has been found to be noncooperative With a Hill coefficient of one (see Fig. |
| Theory of non-cooperative gene induction | The goal is to calculate this function and determine conditions for when it is noncooperative with unit Hill coefficient . |
| Theory of non-cooperative gene induction | In general, the dose-response for this system Will not have unit Hill coefficient [20]. |