Comparing pathogen growth against death rate | This is Why latent Viruses, such as herpes Virus, can go unnoticed from the immune system and persist for long periods of time. |
Discussion | More generally, the huge challenge exerted by the immune system on pathogen populations defacto generates apparent competition between different infection strains (or even species) co-infecting the same host [45]. |
Implications of the model for different cases of immune escape | Chronic infections accumulate much more diversity, in line with the hypothesis that they continuously evolve to evade the immune system [16]. |
Implications of the model for different cases of immune escape | Yet it is known that tumours can mutate immune-checkpoint networks to generate protection from the immune system . |
Introduction | through mutating the p53 tumour suppression gene), and escaping the patient’s immune system are key steps in cancer development [17]. |
Introduction | Existing emergence models have not yet accounted for such within-host population feedbacks, especially those arising from the immune system . |
Author Summary | While it is generally accepted that the immune system plays a key role in HPV clearance, we investigate here a mechanism which could be equally important: the stochastic division dynamics of stem cells in the infected tissues. |
Author Summary | Combining mechanistic mathematical models at the cell-level with population-level data, we disentangle the contributions from immune system and cellular dynamics in the clearance process. |
Author Summary | We find that cellular stochasticity may play an even more important role than the immune system . |
Discussion | Third, we assumed that the interactions between virus and immune system are independent of the specific HPV strains, and that there are no synergistic or competitive effects among co-infecting types, see also [51]. |
Stochasticity vs immune response | In other words, the stochastic dynamics contribute to as much as ~ 83% of the viral clearing mechanism in healthy individuals, and the contribution from the immune system is comparatively small. |