| Gene set functional enrichment analyses | We performed GO and KEGG enrichment analyses in R using the Bioconductor packages Bio-Mart and KEGGgraph, respectively [43, 44]. |
| Gene set functional enrichment analyses | For the KEGG enrichment analysis, as the universe of human proteins, we used the human proteins available in KEGGgraph that participated in at least one KEGG pathway [44]. |
| Putative B. mallei virulence factors improve characterization of B. mallei targets | 1 to identify biological pathways targeted by all tested B. mallei proteins using the Kyoto Encyclopedia of Genes and Genomes ( KEGG ) annotation database [32]. |
| Supporting Information | Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes ( KEGG ) pathways statistically significantly enriched in human proteins interacting with known and/ or putative B. mallei Virulence factors. |
| Abstract | Functional analysis of the respective genetic signatures implicates a wide spectrum of Gene Ontology terms and KEGG pathways with condition-specific information content, including iron transport, transferases, and enterobactin synthesis. |
| Selection of most informative genes and functional enrichment analysis | Various annotations including Gene Ontology terms, KEGG pathways, and InterPro protein domains are investigated. |
| Selection of most informative genes and functional enrichment analysis | Pathway diagrams were re-plotted from the KEGG database [74]. |