Author Summary | Here, we used host-pathogen protein-protein interactions derived from yeast two-hybrid screens to study nine known B. mallei virulence factors and map out potential virulence mechanisms. |
Characteristics of host proteins interacting with known B. mal/ei virulence factors | For the 498-protein set, we found 202 unique proteins that participated in 325 human protein-protein interactions . |
Introduction | mallei protein-protein interactions (PPIs) allowed us to identify three novel B. mallei ATCC 23344 virulence factors and show that they attenuated B. mallei virulence in mouse aerosol challenge experiments. |
Results/Discussion | mallei protein-protein interactions (PPls) was created by merging human-B. |