| Discussion | The spatial heterogeneity of cell traits also leads to a large variation in CSC fraction in biopsy samples, offering yet another angle to the ongoing discussion about the proportion of tumorigenic subpopulations in tumors [38—41]. |
| Methods | Both tumor subpopulations are equipped with migration potential [.1 representing number of potential cell displacements into neighboring lattice sites per day. |
| Spatial phenotypic heterogeneity and implications for tumor biopsy | Single collected biopsy samples can be divided into multiple subpopulations (10 subpopulations with approx. |