| Discussion | We have used a real spike generation mechanism of an actual neuron to study spike responses to artificial PSCs with realistic time courses , distribution of weights and firing statistics of presynaptic neurons [46,47], consistent with experimental observations. |
| Experiment 2. Fully-defined input produced by a population of spiking neurons | There are known differences in the spike statistics and time course of PSCs for different cortical cell types [80]. |
| Prediction of spikes | 7B shows the time course of changes of gain that are due to the post-spike history term and due to the influence of N = 4 inputs included in the model for a typical neuron fit using the grouped model (middle plot). |
| input experiments. | Although detection time likely depends also on presynaptic firing rates as well as time course of PSCs (not just their amplitude), here, for making the comparison clear, pre-synaptic rates for all inputs were held at 5Hz and PSC kernels had the same time course , differing only in amplitude. |