The likelihood of false positives is greatly reduced, but so is the likelihood of identifying true positives .

We use it to further assess the importance of considering asymmetric waveforms, and we eXplore how multiple hypothesis correction impacts the results when the true positives represent a relatively small fraction of the simulated time series, as we eXpect to be the case in genome-wide studies.

The receiver operating characteristic (ROC) curve plots the true positive rate (TPR) as a function of the false positive rate (FPR) as the threshold for calling a time series as a positive is varied.

A score of 1 indicates that a method correctly identified all true positives and true negatives, while a score of —1 indicates that a method yielded all false positives and false negatives.

Within the correctly predicted interactions (i.e., true positives ), we included Flurbiprofen and Ibuprofen detailed information about the network routes.

First, the precision defined as the ratio between the true positives (TP; true drug-protein interactions found by nAnno-Lyze) and the sum of TP and false positives (FP, a link between a drug and a protein not in the PDB).

1A) with an optimal threshold at —2.5 local Z-score resulting in a precision of 0.63 and coverage of 0.19 corresponding to 1,148 true positive predictions (Fig.