Discussion | In our simplified model describing the essential dynamics of the yeast cell cycle process, we assumed the “domino” mechanism of cell cycle regulation , which is different from the previous Tyson’s model [42] and its landscape [9]. |
Discussion | This “domino” mechanism is also found in the cell cycle regulation of higher eukaryotic organisms [43]. |
Introduction | To quantitatively characterize this robustness, and provide a global description of the cell cycle regulatory system, some fundamental questions must be studied. |
Introduction | Our results demonstrate that the energy landscape of the cell cycle is globally attractive, and we show how the cell cycle regulatory network reduces fluctuations from its upstream process and enables long durations in the transition regime. |
Models | Based on the key regulatory network [17] and our previous study on budding yeast [22] , the cell cycle regulatory network can be simplified and separated into G1 /S, early M and late M modules, as shown in Fig. |
Abstract | Transcripts are characterized by decreased halflife: this is considered peculiar of genes involved in regulatory systems with high turnover; consistently, their function affects biological processes such as cell cycle regulation or stress response. |
Discussion | More, we show that ORFs with peak in 3’ UTR share a number of common functions in biological processes such as cell cycle regulation or stress response. |
Discussion | The second one is their enrichment in genes related to cell cycle regulation , apoptosis or similar processes involved in cancer development [65]. |
Discussion | The G2 size control is implemented analogously to the G1 sizer, through biosynthet-ic capacity dependent production of a critical cell cycle regulator . |
Introduction | It is not exactly clear how growth can flip a transition switch, but one theory for size control proposes the level of an unstable cell cycle regulator as a gating device to measure the growth capacity of the cell [25, 26]. |
Introduction | In the model, growth and proliferation is integrated through production of a critical unstable cell cycle regulator as function of the biosynthetic capacity of the cell. |