Discussion | In comparison with direct calculation of all features in a single layer of classification, the two-layer architecture employed in this work reduced average total computational time by a factor of two (S7 Fig). |
Discussion | In this case, the computational time savings associated with the two-layer architecture increases with the complexity of the second-layer relationships and can result in large, roughly sixfold speed improvements in the case of two cell pair identification (88 Fig). |
Results | This two-tier scheme allows significant reduction in computational time . |
Supporting Information | Computational time savings associated with two-layer classification architecture for head versus tail detection. |
Supporting Information | Computational time savings associated with two-layer classification architecture for cell identification. |
Abstract | Unfortunately, once the model is learned, selecting peptides having the greatest predicted bioactivity often requires a prohibitive amount of computational time . |
Author Summary | Indeed, applying the model to every peptides would take an astronomical amount of computer time . |
Author Summary | Therefore, given a model, is it possible to determine, using reasonable computational time , the peptide that has the best properties and chance for success? |
Introduction | I n-silico predictions are faster and cheaper than in-vitro assays, however, predicting the bioactivity of all possible peptide to select the most bioactive ones would require a prohibitive amount of computational time . |
Computational performance | Although INRICH and ALIGATOR show comparable computation times at their lowest SNP p-value cutoff, the need to repeat the analysis at multiple cutoffs means the total analysis for both takes considerably longer. |
Computational performance | The low MAGMA computation times are largely due to the choice of statistical model. |
Computational performance | Note however that the permutation-based SNP-wise analyses in MAGMA also show very reasonable computation times . |
Discussion | However, even the permutation-based SNP-wise models implemented in MAGMA outperformed their equivalents in other software and yielded very reasonable computation times . |
Model for the soft elastic substrate | In order to save computation time , but still keep a high local resolution, local mesh refinement is applied to the top surface. |
Optimization | As this is expensive in terms of computation time , the numerical work is parallelized using the boost thread library [50]. |
Optimization | The computation time on 8 cores of current Intel i7 processors is on the order of 15 minutes per iteration step. |
Cross Validation | We then masked the framework genotypes of the 1,317 individuals whose genomes were not sequenced, imputed the framework genotypes, and calculated the concordance between the imputed and true genotypes over a sample of 53,861 framework SNVs (sorted by base-pair position, every 5th framework SNV was picked instead of using all SNVs to save computing time ). |
Discussion | PRIMAL can be applied to other founder populations or to large families to provide accurate and nearly complete genotype coverage for relatively very small cost and minimal computation time . |
Pedigree-based Imputation | Finding and indexing IBD segments into cliques takes the majority of computing time in the PRIMAL pipeline. |